![]() ![]() Kold sells for $350 and makes soda, ice tea, seltzer, flavored water and more.Īs for the margarita – it tasted good but I would have added a bit more ice to the cup for a true “Kold” experience. In the end, it doesn’t matter – apparently people like to see how a “Kold” Keurig works, even if they already know how the hot one does it. That’s because I was trying to it one handed one handed, while recording the entire drink making process with my phone in my other hand. Bartesian Premium Cocktail and Margarita Machine for The Home Bar with Push-Button Simplicity and an Easy to Clean Design (55300) 4,314 50+ bought in past week 34800 List: 369.99 FREE delivery Jun 28 - 29 More Buying Choices 316. The machine cools down the water, then mixes the drink in the cup.įunny part is that I quip “this is the easiest margarita I’ve ever made” but then I have trouble seating the pod properly in the holder. Then you pop in a new style cup on the pod holder and press start. When he came into the kitchen, he started making us a Keurig coffee as a. All you have to do is put some tequila in the bottom of a cup to get the process started. We both ordered Margarita's, mine on the rocks with salted rim, his blended. ![]() For my sample drink, the company made me a margarita. Kitchen & Food Secure Complete Meal Replacement Bars - 6-count Customer Kitchen HQ Glitz Speed Drum Grater & Slicer Weekly Customer Kitchen HQ Multi-Color. Instead of heating up water, it flash cools water down to 39 degrees in about 60 seconds. A company has developed a device called Bartesian that makes boozy drinks from K-Cup-like capsules. ![]() I was at a press preview event at CES 2016 in Las Vegas and almost passed up the Keurig table because everyone knows how a Keurig works – you pop in a K-Cup and out comes a hot coffee seconds later.īut this one is different – it’s the company’s new Keurig Kold model. Not only is there a Keurig for beer, according to TechCrunch, there is now one for cocktails. At CES you see a lot of gadgets, but I had no idea this one would be so popular – this short video has generated over 29 million plays on my Facebook page! ![]()
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![]() ![]() Middle-earth was joined to Aman in the Northwest by the Helcaraxë, a cold, icy region. Aman was the biggest continent, and it lay in the West, and Middle-earth was to the East. Originally, Arda was flat, and the continents were surrounded by Ekkaia, the Encircling Sea. This resulted in the First War, which marred Arda and changed the plan for its layout. The Valar came up with the geography of Arda and gave it form, until Melkor decided he wanted Arda for himself and tried to fight them for it. Arda was created using the Music of the Ainur, as a way to create a home for the Children of Ilúvatar (the races of Elves and Men). The term Arda simply refers to the world as a whole, the way that we call the planet we inhabit "Earth". RELATED: LOTR: Questions About Middle-Earth That Tolkien Never Answered Arda So what are the differences between these places, and how are they important to Tolkien's world? ![]() Middle-earth, Arda, and Beleriand are all terms that are used when referring to the world Tolkien created, but they all mean different things and may be dependent on what time period is being discussed. One of the more confusing elements is differentiating between the different names for the lands in Tolkien's work, and how the world as a whole is established. The lore goes deep enough that there is a whole mythology surrounding the creation of the world and the extended history of Middle-earth, and because it is secondary to the story, often only the most die-hard fans even know about it. The world Tolkien created is so detailed that there are many places that the story never even visits, but they are still important to the world at large. The lore surrounding The Lord of the Rings is so expansive that it can sometimes be difficult to keep up with. ![]() ![]() ![]() Transitions are the mortar that holds the foundation of the essay together. Clear and logical transitions between the introduction, body, and conclusion.If the student does not master this portion of the essay, it will be quite difficult to compose an effective or persuasive essay. ![]() It is essential that this thesis statement be appropriately narrowed to follow the guidelines set forth in the assignment. Lastly, students should present the thesis statement. Next the author should explain why the topic is important ( exigence) or why readers should care about the issue. In the first paragraph of an argument essay, students should set the context by reviewing the topic in a general way.
![]() ![]() ![]() Subsequently, in 1986 Cohen and Rita Levi-Montalcini were jointly awarded the Nobel Prize in Physiology or Medicine for the discovery of growth factors (see Related links: ). Demonstration that the EGF receptor (EGFR) formed complexes after EGF binding was postulated to be the initial step for cell growth 1. In 1962, Stanley Cohen discovered the protein responsible for incisor and eyelid opening in mice, termed epidermal growth factor (EGF), thus beginning the journey from bench to bedside for HER2-targeted therapy 237, 238. As HER2 is such a sensitive target, continued investigation to advance therapeutic benefit will undoubtedly lead to improvements in survival. ![]() A survey of the landscape of platforms being used to maximize HER2-targeted therapeutic efficacy are enumerated, which includes mAbs, tyrosine kinase inhibitors (TKIs), ADCs, bispecific antibodies, immune system targeting agents, cellular therapy and targeted protein degraders. This Review summarizes the successful therapeutic approaches approved for treatment of HER2 + BC, which are essential to understanding ensuing developments, exploring the potential areas of drug resistance that are the foundation for future drug development. Immunotherapy is being approached from various angles including administering checkpoint inhibitors, linking effector T cells to HER2 antibodies, cellular therapy and vaccines 9, 10, 11, 12. As immunotherapy has shown benefit in triple-negative breast cancer (TNBC), attempts to mobilize the immune system in HER2 + disease are also ongoing. Another approach is the development of bispecific antibodies, which use binding of two different HER2 epitopes to maximize efficacy 9. Therefore, extensive research is ongoing in the preclinical, translational and clinical arenas to develop original and more potent therapies for this exceptionally sensitive target, HER2.Īdvances in targeting HER2 include further exploitation of antibody–drug conjugates (ADCs), altering the linkers, payload or antibody scaffold to optimize efficacy 7, 8. In those HER2 + cancers that do present with de novo stage IV disease or ultimately recur, development of novel therapies is needed as these tumours continue to be dependent on HER2 signalling. As such, the goal of therapy in HER2 + BC is to expand the number of patients cured in the early setting and prevent recurrence. However, despite this success, metastatic HER2 + tumours inevitably develop resistance, leading to disease progression. More than half of patients with metastatic HER2 + disease are diagnosed de novo, further demonstrating that most patients presenting with early disease are cured 6. Currently, survival rates exceed 90% in HER2 + early breast cancer (EBC) treated with chemotherapy and dual antibody therapy 5. The dependence of the tumour on HER2, coupled with effective HER2-targeted drugs such as trastuzumab, pertuzumab and most recently, tucatinib and trastuzumab deruxtecan (T-DXd), have contributed to these survival improvements in patients with HER2-positive (HER2 +) BC 4. However, newer and novel therapeutic strategies have led to markedly improved survival outcomes. Advanced BC was considered incurable, and treatment was purely palliative. Until this point, triple-negative and HER2-overexpressing disease were widely regarded as the most aggressive BC histologies, with unfavourable prognoses. The discovery that amplification or overexpression of HER2 was associated with extremely poor survival in BC ultimately led to the development of a monoclonal antibody (mAb) to HER2, trastuzumab 3 (Box 1). The field was energized in 1978 when the first tyrosine kinase, epidermal growth factor receptor (EGFR), was discovered followed by the identification of the neu or HER2 (also known as ERBB2) gene in 1984 1, 2. Innovations in pathology, molecular biology and drug development have enabled HER2-positive breast cancer (BC), a historically aggressive subtype, to become one with impressive outcomes. ![]() ![]() You can use the drawer for storage of fresh produce, but keep in mind that it doesn’t have an adjustable vent to control humidity or a divider to separate fruits and vegetables. ![]() Inside the 12.1-cubic-foot refrigerator compartment are three adjustable shelves and a full-width drawer. But it’s also available in black stainless steel or white if you need a different finish to match your existing kitchen appliances. The stainless steel finish is fingerprint resistant and a good choice for anyone that wants to worry less about wiping away smudges from the exterior of this frequently used appliance. It has 17.2 cubic feet of capacity and a bottom-freezer configuration that puts fresh foods within easy reach. Total Capacity: 27 cubic feet | Dimensions: 70.25 x 44.875 x 31.625 inches | Installation Depth: Counter | Ice/Water Dispenser: Ice and water | Ice Maker Type: Single | Available Finishes: Stainless steel (with or without viewing window) | Garage Friendly: NoĪ counter-depth refrigerator can fit in your kitchen and your budget if you pick an affordable model, like this version from Hisense. Plan ahead if you’re entertaining, and you anticipate a need for more than the usual amount of ice. An ice maker is handy to have, especially on a hot summer day when you want to enjoy a chilled beverage, but its slow output is one of the biggest gripes about this model. It offers two tiers of storage and a factory-installed ice maker. The 8.7-cubic-foot freezer drawer is roomy, too. A pair of crisper drawers keeps produce fresh and four shelves, plus door bins, give you room to organize everything from condiments to fresh meat. A full-width Glide N' Serve drawer is the perfect spot for keeping your family’s favorite deli meats and cheeses within easy reach. When it comes to fresh food storage, the 17.8 cubic feet of room inside the refrigerator is well-utilized and well-illuminated, thanks to LED interior lighting. Special vents behind the door seal also help to offset warm air entering the refrigerator compartment. On a functional level, LG’s linear cooling design helps to send chilled air to every corner of the unit, ensuring that fridge contents stay cold and fresh. It also enables you better access for filling a pitcher or small pot with fresh, filtered water. It’s worth pointing out that having the water dispenser mounted inside of the refrigerator instead of recessed into the exterior of the door makes this one of the best refrigerators with a streamlined look. In addition to capacity, user-friendly features like an easy-to-open bottom freezer drawer and internal water dispenser make this fridge a great pick. At 29.25 inches deep (without the handle, which adds about 2 more inches), this refrigerator fits seamlessly next to kitchen countertops and adds a sleek look with its modern stainless steel door with a smudge-proof finish. It boasts an impressive 27 cubic feet of space that matches the capacity of many standard-depth refrigerators and maximizes every inch of the refrigerator’s footprint. The LG LRFLC2706S Counter-Depth Max French Door Refrigerator is proof that it’s possible to have maximum storage in a counter-depth model. Each unit was compared based on capacity, durability, value, and range of features. To help you find the best refrigerators with a streamlined look, we researched dozens of counter-depth models from top brands. ![]() One consideration is the amount of space inside due to its depth." The shelves and drawers may not be as spacious as you need or are used to, and you'll want to consider the organizational features before making your big purchase. If you're going to opt for a counter-depth refrigerator, Johnathan Brewer, a licensed general contractor with a specialty in kitchen and bath remodels and The Spruce's Home Improvement Review Board member, notes, "Counter-depth refrigerators look great in a well-designed kitchen. Most models keep the depth to 30 inches or less, but may be a few inches wider or taller to offset some of the lost interior space. "The design of a counter-depth refrigerator is sleeker than a standard refrigerator," says Patricia Davis Brown, an interior designer and Certified Master Kitchen and Bath Designer by the National Kitchen and Bath Association. ![]() ![]() Download Winzip for Mac free full version from links below. WinRAR For Mac & WinRAR Crack is the best file extractor application.Further, WinRAR for PC can run on both 64-Bit and 32-Bit.And WinRAR Apk is easy to use and install than other apps. It has all of the features on Windows, but with a minimilized user interface. As the biggest and oldest file compression technology for more than 20 years, this application had been developed a new zip utility that is amazingly powerful and designed specifically for Mac users. This software is now has been support for RAR extracting, including zip and Bzs formats. Here at you can download the WinRAR archiver for free in English using the links below: For Windows For Android For Linux For Mac OS. ![]() WinRAR Crack With Keygen: WinRAR Crack With Keygen is a multi-language software. So, The files compressed with this program are smaller the size of source. You can also make use archives with this program. Thus, The program has the power to make archives. ![]() Winzip Mac Full Crack Free Download v10.0 – A solution for Mac users who requires RAR unarchiver or RAR extractor on their MacOS device. WinRAR 5.61 Crack full mac windows is a handy program. WinRAR does have a Mac version called RAR for macOS, but it is a command-line only application. Download and use WinRAR to zip and unzip files on your computer. WinRAR is a powerful archive manager providing complete support for RAR and ZIP archives and is able to unpack CAB, ARJ, LZH, TAR, GZ, ACE, UUE, BZ2, JAR, ISO, 7Z, Z archives. Here’s a guide for WinRAR free download 64-bit or 32-bit full version for Windows 11/10/8/7 PC. Winzip Mac Full Crack Free Download v10.0 WinRAR Full Crack downloads are and utility used for compression or zipping utility yon can Zip, compress any doc or video, audio to make u. ![]() ![]() ![]() Wear reduction is related to type, pressure, speed, distance and lubrication.Ī minute portion of the material in contact welds (adheres) and the wear mechanism comes from peeling off of these by shearing force. Wear commonly occurring between metals in sliding contact. (2) Wear from the difference in hardness of two meshing gears in which the hard convex portion digs into the softer gear surface. (1) Possible wear occurring from solid foreign objects mixed in the lubricant (such as metal wear debris, burr, scale, sand, etc.). Wear that looks like an injury from abrasion or has the appearance of lapping. (3) Wear from the hard convex portion of the opposing gear tooth digging into the meshing gear. (2) Wear from a solid foreign object buried for some reason in the opposing gear tooth. ![]() (1) Wear from a solid foreign object larger than the oil film thickness getting caught in the gear mesh. This is part of abrasive wear and the following causes are possibilities. In the direction of gear sliding, groove like condition appears. It is possible for this condition to progress from moderate to break down. This is the condition in which the lubricant coating breaks down due to overheating of local contact areas causing the deterioration of the gear surface from metal to metal contact. These are some of the possible reasons of progressive pitting. (2) While being driven, the load distribution could become uneven across the gear face due to various parts' deflection causing the fatigue limit to become exceeded. (1) When an overload condition exists and the gear surface load exceeds the fatigue limit of the material. Progressive PittingĮven after gear surfaces are worn in and load is equalized, with time more pitting starts to occur and pits get enlarged. As gears are driven and surfaces become worn in, local convex portions disappear and the load is equalized and pitting stops. The initial cause comes from small convex portions of the gear surfaces contacting each other and the local load exceeding the fatigue limit. When the gear surface is repeatedly subjected to load and the force near the contact point exceeds the material's fatigue limit, fine cracks occur and eventually develop into separation of small pieces, thereby creating pits (craters). Transverse module m t = Troubleshooting Gears : Explanation of Terminology Pitting ![]() Normal module ( m n ) = 4 Helix angle ( β ) = 15° Tooth depth (h) is the distance between tooth tip and the tooth root. Please see Figure 2.4 below for explanations for Tooth depth (h) / Addendum (h a) / Dedendum (h f). Introduced here are Tooth Profiles (Full depth) specified by ISO and JIS (Japan Industrial Standards) standards. Tooth depth is determined from the size of the module (m). Dimensions of gears are calculated based on these elements. Module (m), Pressure Angle (α), and the Number of Teeth, introduced here, are the three basic elements in the composition of a gear. They are counted as shown in the Figure 2.3. Number of teeth denotes the number of gear teeth. (Important Gear Terminology and Gear Nomenclature in Fig 2.2) Recently, the pressure angle (α) is usually set to 20°, however, 14.5° gears were prevalent.įig.2.2 Normalized Tooth Profile of Reference Pressure angle is the leaning angle of a gear tooth, an element determining the tooth profile. Gauge Chart TypeĪdd a type attribute to your chart object and set the value to gauge.DP 8 is transformed to module as follows m = 25.4 / 8 = 3.175 Pressure Angle ( α ) Note: See our Gauge Chart Gallery for inspiration on all the different gauge chart possibilities. pyramids radar range rankflow scatter scorecard stock stream sunburst Tile Map tree module Tree Map variwide Vector Plot venn diagram violin waterfall Word Cloud integrations angular AngularJS JQuery nextJS nodeJS phantomJS PHP react svelte vue web component FAQ ZingChart help center getting started your first chart ZingChart branding change log Getting started your first JavaScript chart where to go next adding additional charts anatomy of a ZingChart data basics using the zingsoft studio API JSON configuration events methods build generator custom modules export chart themes ZingChart modules ZingChart object and methods ZingChart render elements graphset labels legend markers media rules mobile charts plot series styling rules scales titles tokens tooltips value boxes widgets features context menu crosshairs dragging drilldown internationalization performance selection shared interactions zoom scroll preview loading data CSV MySQL passing data as JS objects real time feeds using JSON data using PHP and ajax styling 3D charts animation arrows choropleth maps error bars images number formatting patterns shapes themes chart types 3D area bar Box Plot bubble pack bubble pie bubble bullet calendar chord depth flame funnel gauge grid heat map heatmap plugin interactive maps line mixed nested pie organizational diagram pareto pictograph pie pop. ![]() ![]() The company has been especially keen to stress the likely impact of the change on browser performance. Google states that its changes are always driven by the motivation of increasing the security, privacy and performance of Chrome extensions.Īccording to Google software engineer, Devlin Cronin, “It is not, nor has it ever been, our goal to prevent or break content blocking”. All other users will have to rely on declarativeNetRequest as the primary content blocking API. ![]() Now it seems that if you’re a paying enterprise Chrome user, you will still be able to rely on the content-blocking capabilities of webRequest. The argument is that fewer rules would mean a much less comprehensive blocking capability.įast forward to the end of May and there was some partial backtracking on the part of Google. The trouble is that most ad blockers filter content by relying on vast, crowdsourced blacklisting rulesets, which tend to require way more than the declarativeNetRequest 30,000 rule limit. Under declarativeNetRequest, Chrome will basically decide whether to block content based on a ruleset limited to 30,000 individual rules. One change (announced in January) caused particular consternation among developers: for content blocking, Google now wants extensions to use a different API, declarativeNetRequest. Last year, Google started hinting at some of the changes that were in the pipeline as part of its upcoming revised rules for the extensions platform (Manifest V3). ads, pop-up videos and unsafe sites) before this content even reaches the browser. This allows users to filter out and block specified types of content (e.g. ![]() Under it, content-blocking is handled by Chrome’s webRequest API. The current platform for Chrome extensions (Manifest V2) has been in place since 2012. To be included on the Chrome Extensions platform, apps must be built and deployed in accordance with Google’s specifications. small software programs designed to enable users to customise their browsing experience. Add a header to begin generating the table of contents Chrome Ad Blocker Restrictions: What is set to change?Īd blocking applications are extensions: i.e. ![]() ![]() ![]() When Vaughan arrives at Langley, overcrowding and Jim Crow laws have tensions running high, as the American Negro is conflicted in their search for the “double V” (victory abroad, over the Axis powers, and victory at home, over racism and inequality). ![]() Vaughan is a hardworking, frugal, brilliant high school mathematics teacher, mother of four (and later more), who applies to the job at Langley after seeing Butler’s multiple flyers for the position. Langley creates the “West Computers,” named for their segregated space in the West Area, and hires (among other mathematicians) Dorothy Vaughan. Shetterly knows many of these women and their families personally, and as she digs deeper into their stories, she discovers that there are hundreds upon hundreds of them, largely forgotten by history.īlack women were first hired at Langley during the height of WWII, when the NACA personnel manager at the time, Melvin Butler, faced enormous pressure to keep Langley properly staffed during wartime. Hidden Figures opens with a prologue in which the author, Margot Lee Shetterly, outlines her research into the women-particularly black women-who worked as “human computers” at the Langley Research Center in Hampton, Virginia, from the 1940s on. This guide follows Shetterly's example, using the terms that Shetterly includes where she includes them. "Negro." "Colored." "Indian." "Girls." Though some readers might find the language of Hidden Figures discordant to their modern ears, I've made every attempt to remain true to the time period, and to the voices of the individuals represented in this story. Hidden Figuresbegins with the following author's note from Shetterly: ![]() ![]() ![]() The documented whereabouts of the Sudarium have been undisputed since at least 718 A.D., which explains its tremendous significance: If forensic evidence can prove that the Shroud and the Sudarium were in contact with the same body at the time of death, it would tend to invalidate the Carbon-14 results that date the Shroud only to the 14th century. However, the Cloth of Oviedo, venerated in its own right for centuries in this city in Asturias, in north-central Spain, without reference to the Shroud of Turin, stirs far less controversy over its provenance. To many skeptics, the Shroud is at best a pious icon and at worst a medieval hoax. Thus, the various methodologies of investigation have yielded conflicting conclusions, and the mystery remains. While historians sift through lurid alternative theories about crucified Templars and a Masonic Grail, ongoing artistic studies and forensic pathology research on the Shroud of Turin still suggest it may truly be an artifact of first-century Palestine. Some Shroud doubters go further they attempt to speculate on the identity of the man so cruelly crucified to achieve the "fraudulent" image. Clearly, if the Shroud of Turin is a 14th-century artifact, it cannot be the burial cloth of Jesus of Nazareth. ![]() ![]() Those who doubt the authenticity of the Shroud reject all evidence other than the Carbon-14 results, which coincide with the date of the first recorded exhibition of the Shroud in 1357 in Lirey, France. New investigations of the two burial cloths have compared blood types, patterns of stains, facial geometry, and pollen in an effort to find scientific data from the Cloth of Oviedo that might prove whether it covered the same man whose tortured image is preserved on the Shroud.ĭebates about the authenticity of the Shroud of Turin focus on two stumbling blocks: Carbon-14 dating tests in 1988, which placed the origin of the Shroud in the 14th century and lack of documentation to support theories about what happened to Christ's shroud after the resurrection. Hidden from public view for more than a millennium, the Sudarium of Oviedo is thrusting into the modern world fresh testimony about the suffering and death of a man crucified many centuries ago. The history and scientific findings respecting the Sudarium, often called the "Cloth of Oviedo," provide an unfolding story that rivals the most pious fiction.Īs debates have intensified about the Shroud, the 14-foot swath of linen enshrined in the Cathedral of Turin, Italy, that is believed by many to be the burial cloth of Christ, it appears that the Sudarium may be evidence of the authenticity of the Shroud. Shop: Roman Catholic "RC" Brand Original White Logo Collection Pillow | Multiple colors and sizes available!Ī little-known relic in Oviedo, Spain, called the Sudarium, the cloth said to have covered Jesus' face after He was crucified, may be the key to unveiling the mystery of the Shroud of Turin. ![]() |
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